Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.

doi:10.1200/JCO.2007.11.2649

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Article

Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Dec 2007

Austen Belinda, Skowronska Anna, Baker Claire, Powell Judith E, Gardiner Anne, Oscier David, Majid Aneela, Dyer Martin, Siebert Reiner, Taylor A Malcolm, Moss Paul A, Stankovic Tatjana

Abstract excerpt

PURPOSE: The ataxia telangiectasia mutated (ATM) gene is located on chromosome 11q and loss of this region is common in B-cell chronic lymphocytic leukemia (CLL). Our aim was to determine if CLL tumors with a chromosome 11q deletion might be divided into two subgroups based on the status of the remaining ATM allele. METHODS: The sequence of the residual ATM allele was determined in 72 CLLs with an 11q deletion....

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PMID: 17968022
DOI: 10.1200/JCO.2007.11.2649

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Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.PMID 17968022Read ↗

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