IL-28B Genetic Variants Determine the Extent of Monocyte-Induced Activation of NK Cells in Hepatitis C.

doi:10.1371/journal.pone.0162068

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Article

IL-28B Genetic Variants Determine the Extent of Monocyte-Induced Activation of NK Cells in Hepatitis C.

PloS one - 1 Jan 2016

Krämer Benjamin, Finnemann Claudia, Sastre Beatriz, Lutz Philipp, Glässner Andreas, Wolter Franziska, Goeser Felix, Kokordelis Pavlos, Kaczmarek Dominik, Nischalke Hans-Dieter, Strassburg Christian P, Spengler Ulrich, Nattermann Jacob

Abstract excerpt

BACKGROUND: Immuno-genetic studies suggest a functional link between NK cells and λ-IFNs. We recently showed that NK cells are negative for the IFN-λ receptor IFN-λR1 and do not respond to IFN-λ, suggesting a rather indirect association between IL-28B genotype and NK cell activity. METHODS: A total of 75 HCV(+) patients and 67 healthy controls were enrolled into this study. IL-28B (rs12979860) and IFNL-4...

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PMID: 27583440
DOI: 10.1371/journal.pone.0162068
PMCID: PMC5008784

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