Article
Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C.
Hepatology (Baltimore, Md.) - 1 Nov 2011
Golden-Mason Lucy, Bambha Kiran M, Cheng Linling, Howell Charles D, Taylor Milton W, Clark Paul J, Afdhal Nezam, Rosen Hugo R
Abstract excerpt
UNLABELLED: Natural killer (NK) cells constitute a first line of defense against viral infections; their function is governed by the integration of signals from multiple activating and inhibitory surface receptors. We hypothesized that because NKs become rapidly activated by cytokines, response to anti-hepatitis C virus (HCV) therapy would be predicted by the phenotype and function of NKs. We used a cohort of 101...
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