Altered effector functions of NK cells in chronic hepatitis C are associated with IFNL3 polymorphism.

doi:10.1189/jlb.4A1014-520R

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Article

Altered effector functions of NK cells in chronic hepatitis C are associated with IFNL3 polymorphism.

Journal of leukocyte biology - 1 Aug 2015

Rogalska-Taranta Magdalena, Markova Antoaneta A, Taranta Andrzej, Lunemann Sebastian, Schlaphoff Verena, Flisiak Robert, Manns Michael P, Cornberg Markus, Kraft Anke R M, Wedemeyer Heiner

Abstract excerpt

Interferon α-mediated effector functions of NK cells may contribute to the control of HCV replication and the pathogenesis of liver disease. The single-nucleotide polymorphism rs12979860 near IFNL3 (previously known as IL28B) is important in response to IFN-α treatment and in spontaneous resolution of acute hepatitis C. The role of the IFNL3 polymorphism in NK cell function is unclear. Thus, we investigated the...

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PMID: 26034208
DOI: 10.1189/jlb.4A1014-520R

Genes

IFNL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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