Article
Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster.
Nature communications - 1 Sept 2016
Okada Hirokazu, Ebhardt H Alexander, Vonesch Sibylle Chantal, Aebersold Ruedi, Hafen Ernst
Abstract excerpt
The manner by which genetic diversity within a population generates individual phenotypes is a fundamental question of biology. To advance the understanding of the genotype-phenotype relationships towards the level of biochemical processes, we perform a proteome-wide association study (PWAS) of a complex quantitative phenotype. We quantify the variation of wing imaginal disc proteomes in Drosophila genetic...
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