Article
Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster.
Genetics - 1 Jun 2014
Reed Laura K, Lee Kevin, Zhang Zhi, Rashid Lubna, Poe Amy, Hsieh Benjamin, Deighton Nigel, Glassbrook Norm, Bodmer Rolf, Gibson Greg
Abstract excerpt
Systems biology is an approach to dissection of complex traits that explicitly recognizes the impact of genetic, physiological, and environmental interactions in the generation of phenotypic variation. We describe comprehensive transcriptional and metabolic profiling in Drosophila melanogaster across four diets, finding little overlap in modular architecture. Genotype and genotype-by-diet interactions are a major...
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