Article
Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women.
Journal of negative results in biomedicine - 1 Sept 2016
Kitjaroentham Anong, Hananantachai Hathairad, Phonrat Benjaluck, Preutthipan Sangchai, Tungtrongchitr Rungsunn
Abstract excerpt
BACKGROUND: Osteoporosis, characterized by low bone mineral density (BMD) and high bone fracture risk, is prevalent in Thai menopausal women. Genetic factors are known to play a key role in BMD. Low density lipoprotein receptor-related protein 5 (LRP5), a co-receptor in the Wnt/beta-catenin pathway, is involved in many aspects of bone biology. As coding single nucleotide polymorphisms (cSNPs) of LRP5, including...
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