Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women.

doi:10.1016/j.bone.2005.06.025

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Article

Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women.

Bone - 1 Apr 2007

Ezura Yoichi, Nakajima Toshiaki, Urano Tomohiko, Sudo Yoshihiro, Kajita Mitsuko, Yoshida Hideyo, Suzuki Takao, Hosoi Takayuki, Inoue Satoshi, Shiraki Masataka, Emi Mitsuru

Abstract excerpt

Low-density lipoprotein receptor-related protein 5 (LRP5), a co-receptor of Wnt signaling, is an important regulator of bone development and maintenance. Recently we identified correlation between an intronic single-nucleotide polymorphism (SNP) in the LRP5 gene and vertebral bone mineral density (BMD), indicating that a genetic ground exists at this locus for determination of BMD. In the study reported here, we...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Bone Density
Female
Gene Frequency
Genetic Variation
Haplotypes
Humans
Japan
LDL-Receptor Related Proteins
Linkage Disequilibrium

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Low Density Lipoprotein Receptor-Related Protein-5

Middle Aged

Osteoporosis

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Source

Open in PubMed

Identifiers

PMID: 17306638
DOI: 10.1016/j.bone.2005.06.025

Genes

LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.