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Article

inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice.

Blood - 27 Oct 2016

Ellegast Jana M, Rauch Philipp J, Kovtonyuk Larisa V, Müller Rouven, Wagner Ulrich, Saito Yasuyuki, Wildner-Verhey van Wijk Nicole, Fritz Christine, Rafiei Anahita, Lysenko Veronika, Dudkiewicz Ewa, Theocharides Alexandre P, Soldini Davide, Goede Jeroen S, Flavell Richard A, Manz Markus G

Abstract excerpt

Favorable-risk human acute myeloid leukemia (AML) engrafts poorly in currently used immunodeficient mice, possibly because of insufficient environmental support of these leukemic entities. To address this limitation, we here transplanted primary human AML with isolated nucleophosmin (NPM1) mutation and AML with inv(16) in mice in which human versions of genes encoding cytokines important for myelopoiesis...

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Share to Chromosome Aberrations
Share to Chromosomes, Human, Pair 16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

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Source

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Identifiers

PMID: 27581357
DOI: 10.1182/blood-2015-12-689356
PMCID: PMC5084606

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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