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Article

The influence of mutational status and biological characteristics of acute myeloid leukemia on xenotransplantation outcomes in NOD SCID gamma mice.

Journal of cancer research and clinical oncology - 1 Jul 2018

Culen Martin, Kosarova Zdenka, Jeziskova Ivana, Folta Adam, Chovancova Jana, Loja Tomas, Tom Nikola, Bystry Vojtech, Janeckova Veronika, Dvorakova Dana, Mayer Jiri, Racil Zdenek

Abstract excerpt

PURPOSE: This study aimed at analyzing the association of gene mutations and other acute myeloid leukemia (AML) characteristics with engraftment outcomes in immunodeficient mice and to select the engraftment outcomes that best reflect patient survival. METHODS: Mutations in 19 genes as well as leukemia- and patient-related characteristics were analyzed for a group of 47 de novo AML samples with respect to three...

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Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred NOD

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Source

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Identifiers

PMID: 29721667
DOI: 10.1007/s00432-018-2652-2
PMCID: PMC11813402

Genes

NPM1
DNMT3A
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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