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Article

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.

Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2016

Flagmeier Patrick, Meisl Georg, Vendruscolo Michele, Knowles Tuomas P J, Dobson Christopher M, Buell Alexander K, Galvagnion Céline

Abstract excerpt

Parkinson's disease is a highly debilitating neurodegenerative condition whose pathological hallmark is the presence in nerve cells of proteinacious deposits, known as Lewy bodies, composed primarily of amyloid fibrils of α-synuclein. Several missense mutations in the gene encoding α-synuclein have been associated with familial variants of Parkinson's disease and have been shown to affect the kinetics of the...

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Identifiers

PMID: 27573854
DOI: 10.1073/pnas.1604645113
PMCID: PMC5027465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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