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Article

The hemifusion structure induced by influenza virus haemagglutinin is determined by physical properties of the target membranes.

Nature microbiology - 18 Apr 2016

Chlanda Petr, Mekhedov Elena, Waters Hang, Schwartz Cindi L, Fischer Elizabeth R, Ryham Rolf J, Cohen Fredric S, Blank Paul S, Zimmerberg Joshua

Abstract excerpt

Influenza A virus haemagglutinin conformational change drives the membrane fusion of viral and endosomal membranes at low pH. Membrane fusion proceeds through an intermediate called hemifusion(1,2). For viral fusion, the hemifusion structures are not determined(3). Here, influenza virus-like particles(4) carrying wild-type haemagglutinin or haemagglutinin hemifusion mutant G1S(5) and liposome mixtures were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27572837
DOI: 10.1038/nmicrobiol.2016.50
PMCID: PMC4876733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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