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Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery

15 Aug 2022

Abstract excerpt

Chikungunya virus (CHIKV) is a human pathogen that delivers its genome to the host cell cytoplasm through endocytic low pH-activated membrane fusion mediated by class-II fusion proteins. Though structures of prefusion, icosahedral CHIKV are available, structural characterization of virion interaction with membranes has been limited. Here, we have used cryo-electron tomography to visualize CHIKV's complete...

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PMID: 35970990
DOI: 10.1038/s41467-022-32431-9

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