Article
Reversible merger of membranes at the early stage of influenza hemagglutinin-mediated fusion.
Molecular biology of the cell - 1 Jul 2000
Leikina E, Chernomordik L V
Abstract excerpt
Fusion mediated by influenza hemagglutinin (HA), a prototype fusion protein, is commonly detected as lipid and content mixing between fusing cells. Decreasing the surface density of fusion-competent HA inhibited these advanced fusion phenotypes and allowed us to identify an early stage of fusion at physiological temperature. Although lipid flow between membranes was restricted, the contacting membrane monolayers...
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