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Article

Hemagglutinin fusion peptide mutants in model membranes: structural properties, membrane physical properties, and PEG-mediated fusion.

Biophysical journal - 7 Sept 2011

Haque Md Emdadul, Chakraborty Hirak, Koklic Tilen, Komatsu Hiroaki, Axelsen Paul H, Lentz Barry R

Abstract excerpt

While the importance of viral fusion peptides (e.g., hemagglutinin (HA) and gp41) in virus-cell membrane fusion is established, it is unclear how these peptides enhance membrane fusion, especially at low peptide/lipid ratios for which the peptides are not lytic. We assayed wild-type HA fusion peptide and two mutants, G1E and G13L, for their effects on the bilayer structure of...

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Share to Cell Membrane
Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A virus

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Source

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Identifiers

PMID: 21889446
DOI: 10.1016/j.bpj.2011.07.031
PMCID: PMC3164144

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