Article
Structure of influenza haemagglutinin at the pH of membrane fusion.
Nature - 1 Sept 1994
Bullough P A, Hughson F M, Skehel J J, Wiley D C
Abstract excerpt
Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure...
Topics
- Amino Acid Sequence
- Computer Graphics
- Crystallography, X-Ray
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Hydrogen-Ion Concentration
- Membrane Fusion
- Molecular Sequence Data
- Mutation
- Orthomyxoviridae
- Peptide Fragments
- Protein Conformation
- Protein Folding