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Article

The Interaction between Influenza HA Fusion Peptide and Transmembrane Domain Affects Membrane Structure.

Biophysical journal - 15 Dec 2015

Lai Alex L, Freed Jack H

Abstract excerpt

Viral glycoproteins, such as influenza hemagglutinin (HA) and human immunodeficiency virus gp41, are anchored by a single helical segment transmembrane domain (TMD) on the viral envelope membrane. The fusion peptides (FP) of the glycoproteins insert into the host membrane and initiate membrane fusion. Our previous study showed that the FP or TMD alone perturbs membrane structure. Interaction between the influenza...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26682811
DOI: 10.1016/j.bpj.2015.10.044
PMCID: PMC4699882

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