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Article

Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates.

eLife - 19 Feb 2013

Ivanovic Tijana, Choi Jason L, Whelan Sean P, van Oijen Antoine M, Harrison Stephen C

Abstract excerpt

Influenza virus penetrates cells by fusion of viral and endosomal membranes catalyzed by the viral hemagglutinin (HA). Structures of the initial and final states of the HA trimer define the fusion endpoints, but do not specify intermediates. We have characterized these transitions by analyzing low-pH-induced fusion kinetics of individual virions and validated the analysis by computer simulation. We detect initial...

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Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23550179
DOI: 10.7554/eLife.00333
PMCID: PMC3578201

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