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Article

Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression.

Antioxidants & redox signaling - 10 Apr 2017

Klein Diana, Steens Jennifer, Wiesemann Alina, Schulz Florian, Kaschani Farnusch, Röck Katharina, Yamaguchi Masahiro, Wirsdörfer Florian, Kaiser Markus, Fischer Jens W, Stuschke Martin, Jendrossek Verena

Abstract excerpt

AIMS: Radiation-induced normal tissue toxicity is closely linked to endothelial cell (EC) damage and dysfunction (acute effects). However, the underlying mechanisms of radiation-induced adverse late effects with respect to the vascular compartment remain elusive, and no causative radioprotective treatment is available to date. RESULTS: The importance of injury to EC for radiation-induced late toxicity in lungs...

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Identifiers

PMID: 27572073
DOI: 10.1089/ars.2016.6748
PMCID: PMC5393411

Genes

MSC
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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