Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.

doi:10.1126/scitranslmed.aar2041

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Article

Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.

Science translational medicine - 24 Jan 2018

Khan Aadil A, Paget James T, McLaughlin Martin, Kyula Joan N, Wilkinson Michelle J, Pencavel Timothy, Mansfield David, Roulstone Victoria, Seth Rohit, Halle Martin, Somaiah Navita, Boult Jessica K R, Robinson Simon P, Pandha Hardev S, Vile Richard G, Melcher Alan A, Harris Paul A, Harrington Kevin J

Abstract excerpt

Improvements in cancer survival mean that long-term toxicities, which contribute to the morbidity of cancer survivorship, are being increasingly recognized. Late adverse effects (LAEs) in normal tissues after radiotherapy (RT) are characterized by vascular dysfunction and fibrosis causing volume loss and tissue contracture, for example, in the free flaps used for immediate breast reconstruction after mastectomy....

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PMID: 29367346
DOI: 10.1126/scitranslmed.aar2041
PMCID: PMC6020074

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