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Article

Radiation-induced pulmonary fibrosis: roles of therapy-induced senescence and microRNAs

10 Feb 2023

Abstract excerpt

PURPOSE: Progressive, irreversible radiation-induced pulmonary fibrosis (RIPF) is a clinically significant intermediate- to a late-occurring side effect of radiotherapy. Known mechanisms of RIPF include oxidative stress-induced activation of TGF-β with activation of SMAD signaling, TNF-α elaboration, and activation of the Angiotensin Converting Enzyme (ACE) mediated production of angiotensin II with resulting...

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PMID: 36763093
DOI: 10.1080/09553002.2023.2177768

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