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Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades

24 Aug 2017

Abstract excerpt

Radiation-induced pneumonitis and fibrosis represent severe and dose-limiting side effects in the radiotherapy of thorax-associated neoplasms leading to decreased quality of life or - as a consequence of treatment with suboptimal radiation doses - to fatal outcomes by local recurrence or metastatic disease. It is assumed that the initial radiation-induced damage to the resident cells triggers a multifaceted...

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PMID: 28836991
DOI: 10.1186/s13014-017-0865-1

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