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Article

Deciphering the Dynamic Molecular Program of Radiation-Induced Endothelial Senescence.

International journal of radiation oncology, biology, physics - 15 Mar 2022

Benadjaoud Mohamed Amine, Soysouvanh Frédéric, Tarlet Georges, Paget Vincent, Buard Valérie, Santos de Andrade Henrique, Morilla Ian, Dos Santos Morgane, Bertho Annaïg, l'Homme Bruno, Gruel Gaëtan, François Agnès, Mondini Michele, Deutsch Eric, Guipaud Olivier, Milliat Fabien

Abstract excerpt

PURPOSE: Radiation-induced cellular senescence is a double-edged sword, acting as both a tumor suppression process limiting tumor proliferation, and a crucial process contributing to normal tissue injury. Endothelial cells play a role in normal tissue injury after radiation therapy. Recently, a study observed an accumulation of senescent endothelial cells (ECs) around radiation-induced lung focal lesions...

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Identifiers

PMID: 34808254
DOI: 10.1016/j.ijrobp.2021.11.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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