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Article

Thrombopoietin mimetic reduces mouse lung inflammation and fibrosis after radiation by attenuating activated endothelial phenotypes.

JCI insight - 8 Nov 2024

English Jeb, Dhanikonda Sriya, Tanaka Kathryn E, Koba Wade, Eichenbaum Gary, Yang Weng-Lang, Guha Chandan

Abstract excerpt

Radiation-induced lung injury (RILI) initiates radiation pneumonitis and progresses to fibrosis as the main side effect experienced by patients with lung cancer treated with radiotherapy. There is no effective drug for RILI. Sustained vascular activation is a major contributor to the establishment of chronic disease. Here, using a whole thoracic irradiation (WTI) mouse model, we investigated the mechanisms and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39513364
DOI: 10.1172/jci.insight.181330
PMCID: PMC11601560

Genes

MPL
TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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