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Article

Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.

EBioMedicine - 1 Sept 2016

Tuong Zewen Kelvin, Fitzsimmons Rebecca, Wang Shu-Ching Mary, Oh Tae Gyu, Lau Patrick, Steyn Frederik, Thomas Gethin, Muscat George E O

Abstract excerpt

RORα is a member of the nuclear receptor (NR) superfamily and analysis of the (global) RORα-deficient mouse model revealed this NR has a role in glycemic control and fat deposition. Therefore, we generated an adipose-specific RORα 'gain of function' mouse model under the control of the fatty acid binding protein 4 (FABP4) promoter to elucidate the function of RORα in adipose tissue. The Tg-FABP4-RORα4 mice...

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Identifiers

PMID: 27568222
DOI: 10.1016/j.ebiom.2016.08.027
PMCID: PMC5049998

Genes

FABP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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