Article

A Novel Mutation in LXRα Uncovers a Role for Cholesterol Sensing in Limiting Metabolic Dysfunction-Associated Steatohepatitis (MASH)

2024-05-15

Abstract excerpt

Liver x receptor alpha (LXRα, Nr1h3) functions as an important intracellular cholesterol sensor that regulates fat and cholesterol metabolism at the transcriptional level in response to the direct binding of cholesterol derivatives. We have generated mice with a mutation in LXRα that reduces activity in response to endogenous cholesterol derived LXR ligands while still allowing transcriptional activation by synthe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5200d42-4682-5d75-916b-da346d194f75
DOI: 10.1101/2024.05.13.593869

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Novel Mutation in LXRα Uncovers a Role for Cholesterol Sensing in Limiting Metabolic Dysfunction-Associated Steatohepatitis (MASH)DOI 10.1101/2024.05.13.593869Read

A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitisSemantic proximity Read

Damaging mutations in LXRα uncouple lipogenesis from hepatotoxicity and implicate hepatic cholesterol sensing in human liver healthSemantic proximity Read

Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health.Semantic proximity Read

The roles of liver X receptor α in inflammation and inflammation‐associated diseasesSemantic proximity Read

Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)Semantic proximity Read

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.Semantic proximity Read

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.Semantic proximity Read

Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.Semantic proximity Read

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular DiseasesSemantic proximity Read

CXCR3+ LEF1low NK cells cause immunopathological hepatic damage in MASHSemantic proximity Read

The emerging roles of liver X receptors and their ligands in cancerSemantic proximity Read

Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.Semantic proximity Read