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Article

Metabolic Characterization of a Novel RORα Knockout Mouse Model without Ataxia

11 Jul 2017

Abstract excerpt

The retinoic acid receptor-related receptor α (RORα) is a nuclear receptor that plays an important role in regulation of metabolism and the immune system. Genetic models where the receptor is functionally deleted yield mice with significant cerebellar developmental issues associated with severe ataxia. Although many metabolic studies have been performed in these models, the impaired locomotor activity of these...

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PMID: 28744254
DOI: 10.3389/fendo.2017.00141

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