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Article

In vivo definition of cardiac myosin-binding protein C's critical interactions with myosin.

Pflugers Archiv : European journal of physiology - 1 Oct 2016

Bhuiyan Md Shenuarin, McLendon Patrick, James Jeanne, Osinska Hanna, Gulick James, Bhandary Bidur, Lorenz John N, Robbins Jeffrey

Abstract excerpt

Cardiac myosin-binding protein C (cMyBP-C) is an integral part of the sarcomeric machinery in cardiac muscle that enables normal function. cMyBP-C regulates normal cardiac contraction by functioning as a brake through interactions with the sarcomere's thick, thin, and titin filaments. cMyBP-C's precise effects as it binds to the different filament systems remain obscure, particularly as it impacts on the myosin...

Topics

Animals
Binding Sites
Carrier Proteins
Mice
Muscle Contraction
Mutation
Myocardium
Myosins
Protein Binding
Sarcomeres

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27568194
DOI: 10.1007/s00424-016-1873-y
PMCID: PMC5308206

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