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Article

The mechanics of the heart: zooming in on hypertrophic cardiomyopathy and cMyBP-C.

FEBS letters - 1 Mar 2022

Suay-Corredera Carmen, Alegre-Cebollada Jorge

Abstract excerpt

Hypertrophic cardiomyopathy (HCM), a disease characterized by cardiac muscle hypertrophy and hypercontractility, is the most frequently inherited disorder of the heart. HCM is mainly caused by variants in genes encoding proteins of the sarcomere, the basic contractile unit of cardiomyocytes. The most frequently mutated among them is MYBPC3, which encodes cardiac myosin-binding protein C (cMyBP-C), a key regulator...

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Source

Identifiers

PMID: 35224729
DOI: 10.1002/1873-3468.14301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The mechanics of the heart: zooming in on hypertrophic cardiomyopathy and cMyBP-C.PMID 35224729Read ↗

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An Update on MYBPC3 Gene Mutation in Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy-Progress and Novel Therapeutic Opportunities.Semantic proximity Read ↗

Protein haploinsufficiency drivers identify MYBPC3 variants that cause hypertrophic cardiomyopathy.Semantic proximity Read ↗

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Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes.Semantic proximity Read ↗

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Hypertrophic Cardiomyopathy: An Overview of Genetics and ManagementSemantic proximity Read ↗

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Cardiac myosin binding protein C: its role in physiology and disease.Semantic proximity Read ↗

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