Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissociation of structural and functional phenotypes in cardiac myosin-binding protein C conditional knockout mice.

Circulation - 4 Sept 2012

Chen Peter P, Patel Jitandrakumar R, Powers Patricia A, Fitzsimons Daniel P, Moss Richard L

Abstract excerpt

BACKGROUND: Cardiac myosin-binding protein C (cMyBP-C) is a sarcomeric protein that dynamically regulates thick-filament structure and function. In constitutive cMyBP-C knockout (cMyBP-C(-/-)) mice, loss of cMyBP-C has been linked to left ventricular dilation, cardiac hypertrophy, and systolic and diastolic dysfunction, although the pathogenesis of these phenotypes remains unclear. METHODS AND RESULTS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Hormonal
Share to Cardiomyopathy, Hypertrophic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heart Failure

Share to Integrases

Share to Myocardial Contraction

Share to Tamoxifen

Share to Ventricular Function, Left

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 22829020
DOI: 10.1161/CIRCULATIONAHA.111.089219
PMCID: PMC3466088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissociation of structural and functional phenotypes in cardiac myosin-binding protein C conditional knockout mice.PMID 22829020Read ↗

Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice.Semantic proximity Read ↗

Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failureSemantic proximity Read ↗

Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failureSemantic proximity Read ↗

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes.Semantic proximity Read ↗

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.Semantic proximity Read ↗

Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice.Semantic proximity Read ↗

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.Semantic proximity Read ↗

Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomere.Semantic proximity Read ↗

In vivo definition of cardiac myosin-binding protein C's critical interactions with myosin.Semantic proximity Read ↗

Asymmetric septal hypertrophy in heterozygous cMyBP-C null miceSemantic proximity Read ↗

Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.