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Article

Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice.

Circulation research - 22 Mar 2002

Harris Samantha P, Bartley Christopher R, Hacker Timothy A, McDonald Kerry S, Douglas Pamela S, Greaser Marion L, Powers Patricia A, Moss Richard L

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHC) is an inherited autosomal dominant disease caused by mutations in sarcomeric proteins. Among these, mutations that affect myosin binding protein-C (MyBP-C), an abundant component of the thick filaments, account for 20% to 30% of all mutations linked to FHC. However, the mechanisms by which MyBP-C mutations cause disease and the function of MyBP-C are not well understood....

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Source

Identifiers

PMID: 11909824
DOI: 10.1161/01.res.0000012222.70819.64

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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