Article
The impact of HLA-G 3' UTR variants and sHLA-G on risk and clinical correlates of schizophrenia.
Human immunology - 1 Dec 2016
Rajasekaran Ashwini, Shivakumar Venkataram, Kalmady Sunil V, Narayanaswamy Janardhanan C, Subbana Manjula, Venugopal Deepthi, Amaresha Anekal C, Venkatasubramanian Ganesan, Berk Michael, Debnath Monojit
Abstract excerpt
The Major Histocompatibility Complex (MHC)/Human Leukocyte Antigen (HLA) is known to influence the pathogenesis of several complex human diseases resulting from gene-environmental interactions. Recently, it has emerged as one of the risk determinants of schizophrenia. The HLA-G protein (a non-classical MHC class I molecule), encoded by the HLA-G gene, is shown to play important role in embryonic development....
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