Article
Polymorphic sites at the 3' untranslated region of the HLA-G gene are associated with differential hla-g soluble levels in the Brazilian and French population.
PloS one - 1 Jan 2013
Martelli-Palomino Gustavo, Pancotto Joao A, Muniz Yara C, Mendes-Junior Celso T, Castelli Erick C, Massaro Juliana D, Krawice-Radanne Irene, Poras Isabelle, Rebmann Vera, Carosella Edgardo D, Rouas-Freiss Nathalie, Moreau Philippe, Donadi Eduardo A
Abstract excerpt
HLA-G molecule has well-recognized tolerogenic properties, and the encoding gene shows lower frequency of polymorphism at the coding region but higher variability at regulatory 5' and 3' untranslated (3'UTR) regions. At least three 3'UTR polymorphic sites have been associated with HLA-G mRNA regulation, including the 14 base pair (14bp) Insertion/Deletion, +3142C-G and +3187A-G. We studied the association of...
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