Article
The impact of IL10 polymorphisms and sHLA-G levels on the risk of schizophrenia.
Asian journal of psychiatry - 1 Oct 2016
Rajasekaran Ashwini, Shivakumar Venkataram, Kalmady Sunil V, Narayanaswamy Janardhanan C, Subbana Manjula, Venugopal Deepthi, Amaresha Anekal C, Venkatasubramanian Ganesan, Debnath Monojit
Abstract excerpt
Early life immune aberrations have strongly been associated with the risk of schizophrenia. Amongst them, inflammation induced neurodevelopmental origin has emerged as one of the widely recognized underlying mechanisms. Interleukin-10 (IL-10) is an important anti-inflammatory and immunoregulatory cytokine. It modulates the expression of another immuno-inhibitory molecule, Human Leukocyte Antigen-G (HLA-G),...
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