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Article

Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 May 2010

Jowaed Ahmad, Schmitt Ina, Kaut Oliver, Wüllner Ullrich

Abstract excerpt

Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD), and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. We found that methylation of human SNCA intron 1 decreased gene expression, while inhibition of DNA methylation activated SNCA expression. Methylation of SNCA intron 1 was reduced in DNA from sporadic PD patients' substantia nigra, putamen, and cortex,...

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Source

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Identifiers

PMID: 20445061
DOI: 10.1523/JNEUROSCI.6119-09.2010
PMCID: PMC6632710

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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