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Article

Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s disease

7 Feb 2017

Abstract excerpt

Deregulation of α-synuclein encoding gene (SNCA) is one of the important facets of Parkinson's disease (PD) research. DNA methylation status of SNCA-intron1 has been shown to regulate the α-synuclein expression. The present study is aimed at investigating whether methylation of SNCA-intron1 is associated with higher expression of α-synuclein in PD. We have investigated the intron1 methylation status from 16...

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PMID: 28173842
DOI: 10.1186/s13041-017-0285-z

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