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Article

Efficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system.

Theriogenology - 1 Nov 2016

Bevacqua R J, Fernandez-Martín R, Savy V, Canel N G, Gismondi M I, Kues W A, Carlson D F, Fahrenkrug S C, Niemann H, Taboga O A, Ferraris S, Salamone D F

Abstract excerpt

The recently developed engineered nucleases, such as zinc-finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated nuclease (Cas) 9, provide new opportunities for gene editing in a straightforward manner. However, few reports are available regarding CRISPR application and efficiency in cattle. Here, the CRISPR/Cas9...

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Identifiers

PMID: 27566851
DOI: 10.1016/j.theriogenology.2016.06.010

Genes

PRNP

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Source receipt: pubmed, retrieved 7 Sept 2026.

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