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Article

Production of MSTN-mutated cattle without exogenous gene integration using CRISPR-Cas9.

Biotechnology journal - 1 Jul 2022

Gim Gyeong-Min, Kwon Dong-Hyeok, Eom Kyeong-Hyun, Moon JoonHo, Park Ji-Hyun, Lee Won-Wu, Jung Dae-Jin, Kim Dae-Hyun, Yi Jun-Koo, Ha Jae-Jung, Lim Ka-Yeong, Kim Jin-Soo, Jang Goo

Abstract excerpt

Many genome-edited animals have been produced using clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology to edit specific genes. However, there are few guidelines for the application of this technique to cattle. The goal of this study was to produce trait-improved cattle using the genome-editing technology CRISPR-Cas9. Myostatin (MSTN) was selected as a target locus, and synthetic...

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Identifiers

PMID: 34247443
DOI: 10.1002/biot.202100198

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