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Article

Efficient PRNP deletion in bovine genome using gene-editing technologies in bovine cells.

Prion - 1 Jan 2015

Choi WooJae, Kim Eunji, Yum Soo-Young, Lee ChoongIl, Lee JiHyun, Moon JoonHo, Ramachandra Sisitha, Malaweera Buddika Oshadi, Cho JongKi, Kim Jin-Soo, Kim SeokJoong, Jang Goo

Abstract excerpt

Even though prion (encoded by the PRNP gene) diseases like bovine spongiform encephalopathy (BSE) are fatal neurodegenerative diseases in cattle, their study via gene deletion has been limited due to the absence of cell lines or mutant models. In this study, we aim to develop an immortalized fibroblast cell line in which genome-engineering technology can be readily applied to create gene-modified clones for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Encephalopathy, Bovine Spongiform

Share to Genetic Predisposition to Disease

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Share to Promoter Regions, Genetic

Share to Sequence Deletion

Source

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Identifiers

PMID: 26217959
DOI: 10.1080/19336896.2015.1071459
PMCID: PMC4601218

Genes

PRNP
MPG
PRND

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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