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Article

One-Step Homology Mediated CRISPR-Cas Editing in Zygotes for Generating Genome Edited Cattle.

The CRISPR journal - 1 Dec 2020

Park Ki-Eun, Frey Juli Foster, Waters Jerel, Simpson Sean G, Coutu Chris, Plummer Sarah, Campbell Matthew, Donovan David M, Telugu Bhanu P

Abstract excerpt

Selective breeding and genetic modification have been the cornerstone of animal agriculture. However, the current strategy of breeding animals over multiple generations to introgress novel alleles is not practical in addressing global challenges such as climate change, pandemics, and the predicted need to feed a population of 9 billion by 2050. Consequently, genome editing in zygotes to allow for seamless...

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Identifiers

PMID: 33252243
DOI: 10.1089/crispr.2020.0047
PMCID: PMC7757693

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