Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma.

Oncotarget - 7 Feb 2017

Hegyi Marta, Arany Adam, Semsei Agnes F, Csordas Katalin, Eipel Oliver, Gezsi Andras, Kutszegi Nora, Csoka Monika, Muller Judit, Erdelyi Daniel J, Antal Peter, Szalai Csaba, Kovacs Gabor T

Abstract excerpt

Inter-individual differences in toxic symptoms and pharmacokinetics of high-dose methotrexate (MTX) treatment may be caused by genetic variants in the MTX pathway. Correlations between polymorphisms and pharmacokinetic parameters and the occurrence of hepato- and myelotoxicity were studied. Single nucleotide polymorphisms (SNPs) of the ABCB1, ABCC1, ABCC2, ABCC3, ABCC10, ABCG2, GGH, SLC19A1 and NR1I2 genes were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Half-Life
Share to Metabolic Clearance Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methotrexate

Share to Multidrug Resistance-Associated Protein 2

Share to Osteosarcoma

Share to Pharmacogenomic Variants

Share to Pregnane X Receptor

Share to Receptors, Steroid

Source

Open in PubMed Open full text

Identifiers

PMID: 27566582
DOI: 10.18632/oncotarget.11543
PMCID: PMC5354739

Genes

ABCB1
ABCC3
ABCC2
GGH
ABCC1
ABCG2
ABCC10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma.PMID 27566582Read ↗

ABCC2(rs717620), and ABCC3 (rs4793665) affect high dose Methotrexate toxicity, and outcome in children with osteosarcomaSemantic proximity Read ↗

A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial.Semantic proximity Read ↗

Associations of novel genetic variations in the folate-related and ARID5B genes with the pharmacokinetics and toxicity of high-dose methotrexate in paediatric acute lymphoblastic leukaemia.Semantic proximity Read ↗

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma.Semantic proximity Read ↗

Influence of the folate pathway and transporter polymorphisms on methotrexate treatment outcome in osteosarcoma.Semantic proximity Read ↗

Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approachSemantic proximity Read ↗

Advances in individual prediction of methotrexate toxicity: a reviewSemantic proximity Read ↗

Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Pharmacokinetics and pharmacogenetics of high-dose methotrexate in Chinese adult patients with non-Hodgkin lymphoma: a population analysisSemantic proximity Read ↗

Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study.Semantic proximity Read ↗

Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexateSemantic proximity Read ↗

Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.