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Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate

28 Nov 2024

Abstract excerpt

Background: High-dose methotrexate (HD-MTX) is commonly employed in the treatment of malignant tumors in children and young adults due to its distinctive therapeutic efficacy. Nonetheless, the systemic exposure to MTX often results in liver injury (drug induced liver injury, DILI), thereby imposing limitations on the sustained administration of HD-MTX. Additionally, individual variations including genetic...

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Acute Lymphoblastic Leukemia research
Chemotherapy-induced organ toxicity mitigation
Drug-Induced Hepatotoxicity and Protection

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39669197
DOI: 10.3389/fphar.2024.1423214

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