Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma: introducing a haplotype based approach

Abstract excerpt

BACKGROUND: genetic variability for high dose methotrexate (HD-MTX) related toxicities in children and adolescents with acute lymphoblastic leukaemia (ALL) and non Hodgkin malignant lymphoma (NHML). PATIENTS AND METHODS: single nucleotide polymorphisms (SNPs) and haplotypes on HD-MTX induced toxicities. RESULTS: Patients with rs2838958 TT genotype had higher probability for mucositis development as compared to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acute Lymphoblastic Leukemia research
• Share to Childhood Cancer Survivors' Quality of Life