Article
Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia.
Drug metabolism and personalized therapy - 1 Dec 2023
Gurieva Oksana Dmitryevna, Savelyeva Marina Ivanovna, Valiev Timur Tejmurazovich, Sozaeva Zhannet Alimovna, Kondratenko Svetlana Nikolaevna, Ilyin Mikhail Vitalyevich
Abstract excerpt
OBJECTIVES: To evaluate the role of ABCB1 (C3435T rs1045642, rs1128503, rs2032582, rs4148738), SLCO1B1 T521C rs4149056 genetic polymorphisms in the development of major types of methotrexate (MTX) toxicities and the occurrence of a terminal event (death, relapse) in pediatric АLL. METHODS: The study included 124 patients diagnosed with pediatric ALL. All patients treated according to the protocols of the German...