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Article

Advances in individual prediction of methotrexate toxicity: a review

16 Jun 2009

Abstract excerpt

As the cure rates for haematological malignancies have improved, the exploration of the balance between efficacy and side effects has become a major research target. The antifolate methotrexate is widely used in the treatment of acute lymphoblastic leukaemia, non-Hodgkin lymphoma, and osteosarcoma. Even when given identical methotrexate doses, patients vary significantly in their response and pattern of...

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PMID: 19538530
DOI: 10.1111/j.1365-2141.2009.07765.x

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