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ABCC2(rs717620), and ABCC3 (rs4793665) affect high dose Methotrexate toxicity, and outcome in children with osteosarcoma

2020-12-22

Abstract excerpt

<h4>Objectives: </h4> Osteosarcoma (OS) is one of the aggressive bone tumors commonly diagnosed in adolescents and young adults. The study investigated the effect of 9 single nucleotide polymorphisms (SNPs) in 5 genes on methotrexate (MTX) plasma level and its impact on the patients’ clinical outcomes. <h4>Methods:</h4> One hundred and thirty-three patients with OS (68 boys and 65 girls with age range 4.00-17.86 y...

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Literature Corpus work
36b59ed1-f06d-5eed-946d-f7509601407e
DOI
10.22541/au.160862664.48679739/v1
Open publication

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ABCC2(rs717620), and ABCC3 (rs4793665) affect high dose Methotrexate toxicity, and outcome in children with osteosarcomaDOI 10.22541/au.160862664.48679739/v1
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