A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial.

doi:10.1002/jcph.1252

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Article

A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial.

Journal of clinical pharmacology - 1 Dec 2018

Lui Gabrielle, Treluyer Jean-Marc, Fresneau Brice, Piperno-Neumann Sophie, Gaspar Nathalie, Corradini Nadège, Gentet Jean-Claude, Marec Berard Perrine, Laurence Valérie, Schneider Pascale, Entz-Werle Natacha, Pacquement Hélène, Millot Frédéric, Taque Sophie, Freycon Claire, Lervat Cyril, Le Deley Marie Cécile, Mahier Ait Oukhatar Céline, Brugieres Laurence, Le Teuff Gwénaël, Bouazza Naïm

Abstract excerpt

Growing evidence suggests that polymorphisms of genes coding for transporters or enzymes may partially explain the large between subject variability reported for methotrexate (MTX) pharmacokinetics (PK). This prospective study aimed to develop a population PK-pharmacogenetic model to evaluate the part of between-subject variability due to single-nucleotide polymorphisms (SNPs) in transporters and enzyme genes...

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PMID: 29791011
DOI: 10.1002/jcph.1252

Genes

ABCG2
ABCB1
ABCC1
ABCC2
ABCC3
ABCC4

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