Article
Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma.
Oncotarget - 20 Sept 2016
Hattinger Claudia M, Biason Paola, Iacoboni Erika, Gagno Sara, Fanelli Marilù, Tavanti Elisa, Vella Serena, Ferrari Stefano, Roli Andrea, Roncato Rossana, Giodini Luciana, Scotlandi Katia, Picci Piero, Toffoli Giuseppe, Serra Massimo
Abstract excerpt
This study aimed to identify associations between germline polymorphisms and risk of high-grade osteosarcoma (HGOS) development, event-free survival (EFS) and toxicity in HGOS patients treated with neo-adjuvant chemotherapy and surgery.Germline polymorphisms of 31 genes known to be relevant for transport or metabolism of all four drugs used in HGOS chemotherapy (methotrexate, doxorubicin, cisplatin and...
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