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Article

Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer.

BMC pharmacology & toxicology - 27 Feb 2015

Lambrechts Sandrina, Lambrechts Diether, Despierre Evelyn, Van Nieuwenhuysen Els, Smeets Dominiek, Debruyne Philip R, Renard Vincent, Vroman Philippe, Luyten Daisy, Neven Patrick, Amant Frédéric, Leunen Karin, Vergote Ignace

Abstract excerpt

BACKGROUND: This study aimed to determine whether single nucleotide polymorphisms (SNPs) in genes involved in DNA repair or metabolism of taxanes or platinum could predict toxicity or response to first-line chemotherapy in ovarian cancer. METHODS: Twenty-six selected SNPs in 18 genes were genotyped in 322 patients treated with first-line paclitaxel-carboplatin or carboplatin mono-therapy. Genotypes were...

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Identifiers

PMID: 25881102
DOI: 10.1186/s40360-015-0001-5
PMCID: PMC4359565

Genes

ABCC1
ABCC2
ERCC2
ABCA1
ABCB1
ERCC1

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