Article
A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2015
Hagleitner Melanie M, Coenen Marieke J H, Gelderblom Hans, Makkinje Remco R, Vos Hanneke I, de Bont Eveline S J M, van der Graaf Winette T A, Schreuder H W Bart, Flucke Uta, van Leeuwen Frank N, Hoogerbrugge Peter M, Guchelaar Henk-Jan, te Loo Dunja M W M
Abstract excerpt
PURPOSE: Overall survival in patients with osteosarcoma is only 60%. Poor response to chemotherapy is the dominant risk factor for poor survival. Pharmacogenetic research can offer possibilities to optimize treatment and improve outcome. We applied a pathway-based approach to evaluate the cumulative effect of genes involved in the metabolism of cisplatin and doxorubicin in relationship to clinical outcome....
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